Premium
Antiplatelet aggregation principles from Glycosmis citrifolia
Author(s) -
Leu YannLii,
Chan YuYi,
Wu TianShung,
Teng CheMing,
Chen KuoTung
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(1998)12:1+<s77::aid-ptr256>3.0.co;2-j
Subject(s) - acridone , alkaloid , moiety , chemistry , stereochemistry , platelet aggregation , arachidonic acid , platelet , biochemistry , biology , enzyme , immunology
Twelve acridone alkaloids, citracridone‐I ( 1 ), atalaphyllidine ( 2 ), noracronycine ( 3 ), des‐ N ‐methylnoracronycine ( 4 ), 5‐hydroxynor‐acronycine ( 5 ), des‐ N ‐methylacronycine ( 6 ), N ‐methyl severifoline ( 7 ), 5‐hydroxy‐ N ‐methyl severifoline ( 8 ), glycocitrine‐II ( 9 ), 3‐ O ‐methyl‐glycocitrine‐II ( 10 ), glycocitrine‐I ( 11 ) and pyranofoline ( 12 ); one 2‐quinolone alkaloid, 4,8‐dimethoxy‐1‐methyl‐3(3‐methylbut‐2‐enyl)2‐quinolone ( 13 ) were isolated and characterized from the stem and root barks of Glycosmis citrifolia. Their structures were determined by spectral analyses. On bioactive evaluation, compounds 1 and 2 almost completely inhibited platelet aggregation induced by arachidonic acid (100 μ M ), collagen (10 μg/mL) and PAF (2 ng/mL). Compounds 2, 4 and 13 also showed an inhibitory effect on AA and collagen‐induced rabbit platelet aggregation. In the structure and activity relationship of acridone alkaloids, the acridone nucleus bearing a pyranyl moiety is a most important factor for the antiplatelet aggregation activity. © 1998 John Wiley & Sons, Ltd.