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Memory facilitation with atropine: a paradoxical effect
Author(s) -
Ghelardini C.,
Galeotti N.,
Gualtieri F.,
Bellucci C.,
Bartolini A.
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(1998)12:1+<s7::aid-ptr233>3.0.co;2-r
Subject(s) - facilitation , atropine , medicine , anesthesia , parasympatholytic , psychology , neuroscience , muscarinic acetylcholine receptor , receptor
The potential antiamnesic properties of atropine were investigated in the mouse passive avoidance test. Amnesia was induced by scopolamine (2 mg/kg i.p.) and by exposure to a hypoxic environment (5% O 2 in water‐saturated nitrogen) for 8 min. Atropine (1–10 μg/kg s.c.) completely prevented disrupted acquisition without improving learning in mice with memory deficiency. At the same doses atropine did not produce any behavioural side effects in mice. © 1998 John Wiley & Sons, Ltd.