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Antiplatelet and vasorelaxing actions of aporphinoids from Cassytha filiformis
Author(s) -
Wu YangChang,
Chang FangRong,
Chao YaChieh,
Teng CheMing
Publication year - 1998
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(1998)12:1+<s39::aid-ptr244>3.0.co;2-o
Subject(s) - pharmacognosy , traditional medicine , biology , medicine , biological activity , in vitro , biochemistry
Bioassay‐directed fractionation from the methanol extract of the fresh herb of Cassytha filiformis led to the isolation and characterization of six aporphinoid alkaloids, actinodaphnine ( 1 ), N ‐methylactinodaphnine ( 2 ), cathafiline ( 3 ), cathaformine ( 4 ), predicentrine ( 5 ) and ocoteine ( 6 ). They showed potent inhibitory activity of rabbit platelet aggregation induced by adenosine diphosphate (ADP), arachidonic acid (AA), collagen and platelet‐activating factor (PAF) factor. Alkaloids 1 and 2 also exhibited strong inhibition of aortic contraction induced by K + (80 m M ) and norepinephrine (3 μ M ). Moreover, 3 and 4 are two novel aporphinoid alkaloids possessing an N ‐(methoxycarbonyl) group. © 1998 John Wiley & Sons, Ltd.