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Evaluation of diuretic activity of Alternanthera pungens extract in rats
Author(s) -
Calderón C. P.,
García Aseff S. B.,
Fuentes L. B.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199712)11:8<606::aid-ptr163>3.0.co;2-f
Subject(s) - diuretic , furosemide , diuresis , sodium , chemistry , pharmacology , loop diuretic , saline , isotonic saline , excretion , endocrinology , medicine , renal function , biochemistry , organic chemistry
A pharmacological evaluation for diuretic activity of the ethanol extract of Alternanthera pungens was carrried out. Urinary excretion of water, pH, density and sodium concentration were investigated in isotonic saline loaded rats. The extract showed an effective diuretic activity, in comparison with furosemide, increasing significantly the renal loss of sodium. These results indicate that this plant has a diuretic behaviour similar to furosemide, a high‐ceiling diuretic agent. © 1997 John Wiley & Sons, Ltd.