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Contraceptive effects of Phyllanthus amarus extract in the male mouse ( Mus musculus )
Author(s) -
Rao M. V.,
Shah K. D.,
Rajani M.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199712)11:8<594::aid-ptr157>3.0.co;2-4
Subject(s) - sterility , sperm , biology , fertility , andrology , ratón , adverse effect , pharmacognosy , physiology , endocrinology , medicine , traditional medicine , pharmacology , biological activity , biochemistry , botany , population , in vitro , environmental health
Feeding an alcohol extract of Phyllanthus at a dose of 500 mg/kg for 45 days induced gradual inhibition of fertility potential in male albino mice with a decline in epididymal sperm profiles. However, no effects were observed in gravimetric analysis. Similarly no adverse changes were found in the blood biochemical profile and cell counts. Upon withdrawal of feeding the extract to mice, the observed antifertility effects were reversed gradually, indicating induction of functional sterility. © 1997 John Wiley & Sons, Ltd.