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Effect of Pfaffia iresinoides on the experimental inflammatory process in rats
Author(s) -
Taniguchi Shirley F.,
BersaniAmado Ciomar A.,
Sudo Lia S.,
Assef Silvana M. C.,
Oga Seizi
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199712)11:8<568::aid-ptr164>3.0.co;2-3
Subject(s) - pleurisy , saponin , granuloma , arthritis , freund's adjuvant , adjuvant , aqueous extract , medicine , carrageenan , pharmacology , inflammation , traditional medicine , immunology , chemistry , pathology , alternative medicine , pleural effusion
Antiinflammatory activities of aqueous and saponin extracts and ecdysterone obtained from Pfaffia iresinoides (Sprengel) were studied by using three experimental inflammatory models in rats. The saponin extract (25 and 50 mg/kg, p.o.) reduced the leukocyte migration, particularly of mononuclear cells in the carrageenin‐induced pleurisy. It also inhibited the granuloma tissue formation following cotton pellet implantation and the complete Freund's adjuvant‐induced arthritis. The aqueous extract, in the same conditions, was effective on both carrageenin‐induced pleurisy and complete Freund's adjuvant arthritis. However, it did not alter the granuloma formation. The ecdysterone (5 mg/kg, p.o.), isolated from P. iresinoides , showed no effect on these inflammatory processes. © 1997 John Wiley & Sons, Ltd.