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The effects of essential oil of Mentha x villosa on skeletal muscle of the toad
Author(s) -
Fogaça R. T. H.,
Cavalcante A. D. A.,
Serpa A. K. L.,
Sousa P. J. C.,
CoelhodeSouza A. N.,
LealCardoso J. H.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199712)11:8<552::aid-ptr154>3.0.co;2-n
Subject(s) - toad , contraction (grammar) , muscle contraction , sartorius muscle , chemistry , biophysics , anatomy , skeletal muscle , contractility , caffeine , medicine , endocrinology , biology
The effects of the essential oil of Mentha x villosa (EOMV) was investigated in saponin‐permeabilized fibres and in intact sartorius muscle of the toad. In intact muscle EOMV at concentrations from 1 to 100 μg/mL blocked the contraction induced by high (80 m M ) potassium and induced potentiation of caffeine‐induced muscle contraction. From 1 to 6 mg/mL EOMV elicited contraction in both depolarized (by 110 m M K + ) and non‐depolarized (4 m M K + ) muscle fibres. This contraction was blocked by procaine. At 3 mg/mL EOMV depolarized the normal resting potential from −80.77 to −71.21 mV, but did not alter the transmembrane potential in the presence of 60 m M K + . EOMV (1 mg/mL) induced contraction of saponin‐permeabilized muscle fibres with an intact sarcoplasmic reticulum (SR). These data suggest that EOMV: (i) induces muscle contraction by releasing Ca 2+ from SR; (ii) impairs the excitation–contraction coupling at a step before Ca 2+ release from the SR. © 1997 John Wiley & Sons, Ltd.