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Jatropha curcas extract causes anaemia in rat
Author(s) -
Oluwole F. S.,
Bolarinwa A. F.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199711)11:7<538::aid-ptr147>3.0.co;2-3
Subject(s) - jatropha curcas , toxicity , euphorbiaceae , acute toxicity , red blood cell , traditional medicine , medicine , biology , zoology , physiology , botany
An investigation into the possible effects of the methanol extract of Jatropha curcas on some haematological parameters was carried out on male albino rats. The extract was observed to cause a progressive reduction in the measured haematological values (packed cell volume, haemoglobin concentration and red cell counts). The reduction in values of red blood cell counts and haemoglobin concentration were significantly ( p <0.01) pronounced in 8 day and 10 day treated rats compared with the control. The LD 50 in the acute toxicity test in mice was 25.19 mg. The results suggest that Jatropha curcas most likely caused macrocytic hypochromic type of anaemia in rats. © 1997 John Wiley & Sons, Ltd.