Premium
Further study of antiinflammatory effects of Abies pindrow
Author(s) -
Singh R. K.,
Pandey B. L.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199711)11:7<535::aid-ptr146>3.0.co;2-f
Subject(s) - terpenoid , medicine , traditional medicine , glycoside , pharmacology , adjuvant , chemistry , stereochemistry , immunology
Abies pindrow leaves are used as an Ayurvedic remedy for disorders with inflammatory symptoms. The antiinflammatory effect was established in preliminary studies. Fractional extraction of the leaves indicated uneven predominance of flavonoids, glycosides, terpenoids and steroids. An antiinflammatory effect in the 5 h carrageenin oedema model was exhibited by all fractions, indicating multiple active principles. Studies in granuloma pouch and adjuvant arthritis models in rats also indicated a significant antiinflammatory effect. The polar constituents were more inhibitory to acute, while non‐polar ones prominently inhibited the chronic inflammatory reactions. No immunomodulatory effect could be indicated as such. © 1997 John Wiley & Sons, Ltd.