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Hepatoprotective flavonol glycosides of Saururus chinensis herbs
Author(s) -
Sung Sang Hyun,
Kwon Soo Hyun,
Cho Nam Jin,
Kim Young Choong
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199711)11:7<500::aid-ptr139>3.0.co;2-p
Subject(s) - glycoside , toxicity , chemistry , glutathione , pharmacology , quercetin , sorbitol dehydrogenase , traditional medicine , biochemistry , antioxidant , sorbitol , medicine , stereochemistry , enzyme , organic chemistry
Two flavanol glycosides, quercetin‐3‐ O ‐β‐ D ‐glucuronopyranoside (1) and quercetin‐3‐ O ‐β‐ D ‐glucuronopyranosyl methyl ester (2), from the aerial part of Saururus chinensis which possess hepatoprotective activities have been identified. Both compounds 1 and 2 significantly reduced the level of glutamic pyruvic transaminase released from intoxicated rat hepatocytes and resulted in 78% and 82% blockade of the toxicity at 200 μ M , respectively. Furthermore, these compounds also reduced the level of toxicity as measured by the release of sorbitol dehydrogenase and resulted in 76% and 83% blockade of the toxicity at 200 μ M , respectively. Also, these glycosides significantly increased the activity of glutathione‐S‐transferase in the injured rat hepatocytes and resulted in 68% and 86% blockade of the toxicity at 200 μ M , respectively. Finally, these flavonol glycosides promoted the preservation of glutathione in carbon tetrachloride‐intoxicated hepatocytes by 46% and 52% of the untreated control, respectively. © 1997 John Wiley & Sons, Ltd.