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Effect of herbal medicine (Sho‐seiryu‐to and Ryo‐kan‐kyo‐mi‐shin‐ge‐nin‐to) on human eosinophil biological function
Author(s) -
Okubo Yoshio,
Hossain Mahboob,
Horie Shiro,
Momose Tomoyasu,
Suzuki Junichi,
Isobe Mitsuaki,
Sekiguchi Morie
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199711)11:7<485::aid-ptr133>3.0.co;2-n
Subject(s) - eosinophil , degranulation , medicine , granulocyte macrophage colony stimulating factor , pharmacology , immunology , integrin alpha m , cytokine , immune system , receptor , asthma
The effects were examined of Sho‐seiryu‐to and Ryo‐kan‐mi‐shin‐ge‐nin‐to on the degranulation, expression of adhesion molecules and viability of human eosinophils. Eosinophil degranulation by granulocyte/macrophage‐colony stimulating factor (GM‐CSF) and platelet activating factor (PAF) was significantly inhibited in a dose dependent fashion by Sho‐seiryu‐to and Ryo‐kan‐kyo‐mi‐shin‐ge‐nin‐to. Mean fluorescence intensity (MFI) of constitutively expressed CD11b/CD18 on eosinophils was augmented by GM‐CSF or PAF stimulation; however, the increased CD11b/CD18 expression on eosinophils was significantly down‐regulated by Sho‐seiryu‐to. Eosinophil survival in the presence of recombinant human interleukin‐5 in vitro was significantly inhibited by 1000 μg/mL of Sho‐seiryu‐to and Ryo‐kan‐kyo‐mi‐shin‐ge‐nin‐to, which possess an inhibitory effect on eosinophil function, suggesting their usefulness in the treatment of allergic diseases. © 1997 John Wiley & Sons, Ltd.