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Extracts of Bolivian plants, Copaifera reticulata and Heisteria pallida inhibit in vitro free radical‐mediated DNA damage
Author(s) -
Desmarchelier C.,
Coussio J.,
Ciccia G.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199709)11:6<460::aid-ptr125>3.0.co;2-x
Subject(s) - deoxyribose , antioxidant , chemistry , dichloromethane , traditional medicine , methanol , pharmacognosy , ic50 , in vitro , dna damage , biochemistry , botany , dna , biology , biological activity , organic chemistry , solvent , medicine
The presence of different extracts of antiinflammatory plants Copaifera reticulata and Heisteria pallida in a reaction medium containing calf thymus DNA in a free radical generating system protected DNA against oxidative damage in terms of deoxyribose oxidation. The highest antioxidant activity was obtained using the methanol extract of C. reticulata (IC 50 =3 μg/mL), followed by the aqueous extracts of H. pallida (IC 50 =257 μg/mL) and C. reticulata (IC 50 =380 μg/mL). Both dichloromethane extracts and the methanol extract of H. pallida showed a decreased antioxidant activity at higher concentrations. These results suggest that these extracts are capable of suppressing the in vitro oxidative degradation of DNA. © 1997 John Wiley & Sons, Ltd.