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Endothelium‐dependent vasodilator effect of extract prepared from the seeds of Areca catechu on isolated rat aorta
Author(s) -
Goto Hirozo,
Tanaka Nobumitsu,
Tanigawa Kiyoaki,
Shimada Yutaka,
Itoh Takashi,
Terasawa Katsutoshi
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199709)11:6<457::aid-ptr123>3.0.co;2-j
Subject(s) - aorta , vasodilation , endothelium , semen , muscarinic acetylcholine receptor , agonist , chemistry , pharmacology , medicine , endocrinology , traditional medicine , receptor , anatomy
Arecae semen extract relaxed aortic ring preparations of isolated rat aorta that contained endothelium from 3×10 −7 g/mL, reaching a maximum of 86% at 10 −5 g/mL. Its relaxation did not occur in specimens without endothelium, and was inhibited by pretreatment with 10 −4 M N G ‐nitro‐1‐arginine methylester. One of the active components was arecoline which is a muscarinic receptor agonist. Another active component was condensed tannin contained in Arecae semen. © 1997 John Wiley & Sons, Ltd.