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Antioxidative activity of flavones and flavonols in vitro
Author(s) -
Yokozawa Takako,
Dong Erbo,
Liu Zhong Wu,
Shimizu Mineo
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199709)11:6<446::aid-ptr128>3.0.co;2-8
Subject(s) - flavones , lipid peroxidation , in vitro , antioxidant , chemistry , hydroxyl radical , flavonoid , biological activity , biochemistry , scavenging , stereochemistry , structure–activity relationship , traditional medicine , medicine , chromatography
Forty‐one flavonoids of the flavone and flavonol types were investigated for their antioxidative activity using a lipid peroxidation generation system mediated by the addition of H 2 O 2 /Fe 2+ to rat liver homogenate. The results showed that both types specifically and markedly reduced the production of peroxidants induced by H 2 O 2 , Fe 2+ or a Fenton‐type reaction. The scavenging ability of these compounds was found to be associated closely with their chemical structure, especially the number of hydroxyl groups linked to the basic skeleton. However, there were some exceptions, implying that not only hydroxyl groups but also their configuration determines the activity. © 1997 John Wiley & Sons, Ltd.