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Screening of 17 Guatemalan medicinal plants for platelet antiaggregant activity
Author(s) -
Villar Rosa,
Calleja José María,
Morales Claudia,
Cáceres Armando
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199709)11:6<441::aid-ptr126>3.0.co;2-t
Subject(s) - pharmacognosy , traditional medicine , thrombin , phytotherapy , platelet , biology , botany , medicine , biological activity , in vitro , biochemistry , immunology , alternative medicine , pathology
The platelet antiaggregant activity of 17 aqueous extracts of plants traditionally used in Guatemala for the treatment of ‘blood disorders’ and parasitic infections were assayed. The aggregation of washed human platelets induced by thrombin (0.075 U/mL) was inhibited by extracts of Tridax procumbens , Tagetes lucida , Annona reticulata , Neurolaena lobata , Bixa orellana , Rauvolfia tetraphylla , Petiveria alliacea and Tecoma stans. The other extracts did not have clear inhibitory effects, and indeed caused some platelet aggregation themselves, in the absence of thrombin. © 1997 John Wiley & Sons, Ltd.