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Effect of ginseng pretreatment on cerebral glucose metabolism in ischaemic rats using animal positron emission tomography (PET) and [ 18 F]‐FDG
Author(s) -
Choi Seok Rye,
Magata Yasuhiro,
Saji Hideo,
Tajima Ken,
Kitano Haruhiro,
Konishi Junji,
Yokoyama Akira
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199709)11:6<437::aid-ptr124>3.0.co;2-i
Subject(s) - positron emission tomography , ginseng , medicine , brain positron emission tomography , nuclear medicine , carbohydrate metabolism , metabolism , positron , pharmacognosy , pharmacology , in vivo , chemistry , biological activity , preclinical imaging , biochemistry , biology , pathology , physics , in vitro , alternative medicine , quantum mechanics , electron , microbiology and biotechnology
To investigate the effect of ginseng on damaged brain activity, we evaluated the cerebral metabolic rate of glucose (CMRglc) as a functional index in post‐ischaemic rats and compared the results with those obtained after the administration of a ginseng extract. CMRglc was measured using high resolution animal positron emission tomography with 18 F‐2‐fluoro‐2‐deoxy‐D‐glucose ( 18 F‐FDG). The rats subjected to a 30‐min occlusion showed a significant reduction of k3, the rate constant for phosphorylation of 18 F‐FDG by hexokinase, compared with the normal value. The ginseng pretreatment prevented the reduction in k3 and CMRglc caused by ischaemia. Although further investigation is needed to elucidate the mechanism of action, ginseng may be useful for prevention and treatment of ischaemia. © 1997 John Wiley & Sons, Ltd.