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A human immunodeficiency virus protease inhibitory substance from Swietenia mahagoni
Author(s) -
Matsuse Ines Tomoco,
Nakabayashi Takeshi,
Lim Yasmina Aura,
Hussein Ghazi M. E.,
Miyashiro Hirotsugu,
Kakiuchi Nobuko,
Hattori Masao,
Stardjo Supriyatna,
Shimotohno Kunitada
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199709)11:6<433::aid-ptr122>3.0.co;2-#
Subject(s) - inhibitory postsynaptic potential , bark (sound) , protease , hiv 1 protease , traditional medicine , enzyme , pharmacognosy , fractionation , biology , chlorogenic acid , chemistry , biochemistry , biological activity , botany , in vitro , chromatography , medicine , ecology , neuroscience
For the purpose of finding anti‐HIV agents from natural sources, various plant extracts were screened for their inhibitory activity against HIV‐protease, an enzyme essential for viral proliferation. By bioassay‐directed fractionation of the methanol extract of Swietenia mahagoni (bark) which had shown inhibitory activity against this enzyme, we isolated and identified chlorogenic acid methyl ester as a inhibitory substance, its 50% inhibitory concentration being less than 40 μg/ml. © 1997 John Wiley & Sons, Ltd.