Premium
Comparative study on the immunocompetent activity of three different kinds of Peh‐Hue‐Juwa‐Chi‐Cao, Hedyotis diffusa , H. corymbosa and Mollugo pentaphylla after sublethal whole body x‐irradiation
Author(s) -
Yang JenqJer,
Hsu HsueYin,
Ho YauHui,
Lin ChunChing
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199709)11:6<428::aid-ptr121>3.0.co;2-p
Subject(s) - immunocompetence , leukopenia , pharmacology , traditional medicine , medicine , biology , chemistry , toxicity , immunology , immune system
This brief communication describes the immunocompetent activity of the Chinese folk‐medicinal herbs, Hedyotis corymbosa , H. diffusa and Mollugo pentaphylla in mice after moderate whole body x‐irradiation. These antitumour drugs, given at doses of 500 and 1000 mg/kg/day for 7 consecutive days before x‐irradiation protected ICR strain mice from the sublethal effects of radiation at a dose of 4 Gy, especialy for the dose at 1000 mg/kg. Prior administration of H. corymbosa and H. diffusa ameliorated the leukopenia and splenic cellular decrease induced by sublethal irradiation, and slightly increased the immunocompetence of splenic cells after being stimulated by mitogens. However, administration of M. pentaphylla before x‐irradiation exerted a less protective effect on ameliorating leukopenia and on splenic cellular immunocompetence. These findings suggest that some types of Peh‐Hue‐Juwa‐Chi‐Caoi (PHJCC) may also be effective in the prevention of haematopoietic damage when used in combination with radiotherapy. © 1997 John Wiley & Sons, Ltd.