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Angiotensin converting enzyme inhibiting and anti‐dipsogenic activities of Euphorbia hirta extracts
Author(s) -
Williams L. A. D.,
GossellWilliams M.,
Sajabi A.,
Barton E. N.,
Fleischhacker R.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199708)11:5<401::aid-ptr119>3.0.co;2-t
Subject(s) - pharmacology , traditional medicine , angiotensin converting enzyme , angiotensin ii , enzyme inhibitor , medicine , renin–angiotensin system , enzyme , chemistry , receptor , biochemistry , blood pressure
The methanol extract obtained from the leaves and stems of Euphorbia hirta inhibited the activity of angiotensin converting enzyme (ACE) by 90% and 50% at 500 μg and 160 μg respectively using enzyme linked immunosorbent assay (ELISA). The effect of the extract on thirst was examined using Wistar rats. Intraperitoneal administration of 10 mg/100 mg body wt of the extract significantly ( p <0.05) decreased the amount of water consumed by rats. This effect lasted for 2 h. © 1997 John Wiley & Sons, Ltd.