Premium
Sedative activity in mice of a hydroalcohol extract of Hypericum perforatum L.
Author(s) -
Gîrzu Mihaela,
Carnat Andrée,
Privat AnneMarie,
Fialip Joseph,
Carnat AndréPaul,
Lamaison JeanLouis
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199708)11:5<395::aid-ptr114>3.0.co;2-q
Subject(s) - hypericin , sedative , hypericum perforatum , diazepam , sedation , pharmacognosy , chemistry , traditional medicine , flavones , pharmacology , chromatography , biological activity , medicine , in vitro , biochemistry
The sedative activity of a hydroalcohol extract of Hypericum perforatum L. (Hypericaceae) and some of its isolated constituents was evaluated in mice. A dry hydroalcohol extract, orally administered at 26.5 mg/kg, induced a marked sedation as measured by two different tests (actimeter and sleep potentiation), compared with controls (diazepam, 2 mg/kg, per os ). Several fractions were isolated from this hydroalcohol extract: hypericin, flavones, butanol fraction, aqueous fraction; a separation and purification method was developed for hypericin. None of the isolated fractions exhibited the same sedative activity as the hydroalcohol extract. © 1997 John Wiley & Sons, Ltd.