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Antispermatogenic effect of chromatographic fractions isolated from petroleum ether extract of Mentha arvensis leaf in the albino mouse
Author(s) -
Sharma Nidhi,
Jacob Dennis
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199708)11:5<386::aid-ptr107>3.0.co;2-g
Subject(s) - petroleum ether , chloroform , ether , chromatography , chemistry , methanol , biology , traditional medicine , toxicology , medicine , organic chemistry , extraction (chemistry)
Abstract The antifertility activity of column chromatographically isolated fractions (petroleum ether:benzene 1:1 v/v and chloroform:methanol 1:1 v/v) of a petroleum ether extract of Mentha arvensis leaf were evaluated in the male albino mouse. Administration of the fractions for 20 days at a dose of 1.0 mg/mouse/alternate day reduced the wet weights of genital organs and induced infertility in the male mouse without loss of libido as evaluated by sterile matings with normal proestrus females. Absence of spermatozoa in the cauda epididymes as a consequence of spermatogenic arrest is considered contributory to the antifertility effect. © 1997 John Wiley & Sons, Ltd.