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Analgesic and central depressor effects of the dichloromethanol extract from Schinus molle L.
Author(s) -
Barrachina M. D.,
Bello R.,
MartínezCuesta M. A.,
PrimoYúfera E.,
Esplunges J.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199706)11:4<317::aid-ptr91>3.0.co;2-m
Subject(s) - analgesic , pharmacognosy , toxicity , acute toxicity , chemistry , pharmacology , traditional medicine , fractionation , biological activity , medicine , in vitro , chromatography , biochemistry , organic chemistry
The analgesic and central depressor effects of the dichloromethanol extract of Schinus molle L. were analysed in in vivo models. This extract showed low acute toxicity, CNS depressor activity and analgesic effect. Following further fractionation, the hexane/dichloromethane (75/25) fraction showed the most interesting results. Thus, this fraction caused a total inhibition of motor activity and significantly reduced the threshold of pain to chemical stimulus. © 1997 John Wiley & Sons, Ltd.