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Effects of diets containing seeds of Garcinia kola (Heckel) on gastric acidity and experimental ulceration in rats
Author(s) -
Ibironke G. F.,
Olaleye S. B.,
Balogun O.,
Aremu A.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199706)11:4<312::aid-ptr88>3.0.co;2-7
Subject(s) - pharmacognosy , traditional medicine , gastric acid , medicine , chemistry , gastroenterology , stomach , biological activity , biochemistry , in vitro
The antiulcerogenic and gastric acid lowering effects of Garcinia kola (Heckel) seeds were investigated in male albino rats. The animals were fed for 2 weeks on normal rat diets but specially composed to contain 25%, 50% and 75% by weight of G. kola . It was observed that G. kola produced a dose‐dependent inhibition of gastric acid secretion and indomethacin‐induced ulceration. We suggest that this might be due to its acid‐lowering effect and increased mucus production among other factors yet to be determined. © 1997 John Wiley & Sons, Ltd.