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Antiinflammatory and antibacterial activities of C‐methylflavonols from Piliostigma thonningii
Author(s) -
Ibewuike Joseph C.,
Ogungbamila Francis O.,
Ogundaini Abiodun O.,
Okeke Irukaku N.,
Bohlin Lars
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199706)11:4<281::aid-ptr281>3.0.co;2-9
Subject(s) - ether , antibacterial activity , dimethyl ether , chemistry , kaempferol , stereochemistry , quercetin , traditional medicine , biology , organic chemistry , methanol , medicine , antioxidant , bacteria , genetics
Newly described C‐methylflavonols, 6,8‐di‐C‐methylquercetin 3‐methyl ether, 6‐C‐methylquercetin 3,7‐dimethyl ether, 6,8‐di‐C‐methylquercetin 3,7‐dimethyl ether together with the known compounds quercetin, quercitrin, 6‐C‐methylquercetin 3‐methyl ether, 6‐C‐methylquercetin 3,7,3′‐trimethyl ether, 6,8‐di‐C‐methyl‐ kaempferol 3‐methyl ether and 6,8‐di‐C‐methylkaempferol 3,7‐dimethyl ether isolated from the leaves of Piliostigma thonningii , were tested for their ability to inhibit prostaglandin synthesis in vitro and antibacterial activity against Staph. aureus . The influence of the B ring 3′,4′ diol group on the activity of C‐methylflavonols in the inhibition of prostaglandin synthesis differ from that observed for a series of flavonoids without C‐methyl groups. The antibacterial activity in the series mirror those of methylated antimicrobial flavonoids. The traditional uses of the plant in infections and inflammatory conditions were rationalized on the basis of the activities of these compounds. © 1997 John Wiley & Sons, Ltd.