Premium
Experimental evaluation of protective activity of Echinacea pallida against cisplatin toxicity
Author(s) -
Mustea I.,
Postescu I. D.,
Tamas M.,
Rasnita T. D.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199705)11:3<263::aid-ptr77>3.0.co;2-0
Subject(s) - toxicity , cisplatin , pharmacognosy , traditional medicine , pharmacology , biology , medicine , toxicology , biological activity , in vitro , chemotherapy , surgery , biochemistry
The hydroalcohol standardized extract of E. pallida Nutt. given to mice p.o. in association with the i.p. administration of cisplatin exhibited protective effects expressed by a diminished loss and a faster recovery of the animal's body weight. Pretreatment with E. pallida also decreased cisplatin nephrotoxicity estimated from the level of kidney homogenate oxygen consumption. © 1997 John Wiley & Sons, Ltd.