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Hypotensive effect of O‐methylisothalicberine, a bisbenzylisoquinoline alkaloid isolated from Berberis chilensis on normotensive rats
Author(s) -
Martínez J. L.,
Torres R.,
Morales M. A.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199705)11:3<246::aid-ptr62>3.0.co;2-j
Subject(s) - tetrandrine , brine shrimp , alkaloid , berberidaceae , artemia salina , berberis , menispermaceae , chemistry , pharmacology , traditional medicine , biology , stereochemistry , medicine , toxicity
O‐Methylisothalicberine (O‐MI) is a bisbenzylisoquinoline alkaloid isolated from Berberis chilensis , structurally similar to alkaloids previously described in the literature as calcium antagonists of natural origin (berbamine, tetrandrine, antioquine, 7‐O‐demethylisothalicberine and others). O‐MI caused a significant reduction of mean arterial pressure (MAP) in normotensive anaesthetized rats. Doses of 1.0; 2.5; 5.0; 7.5 and 10.0 mg/kg were administered via the femoral vein. MAP was reduced by 5.8%; 10.1%; 35.6%; 67.9% and 60.5% respectively. The onset of hypotensive action was 5 s after 5 mg/kg i.v. and the effect lasted for about 120 s. O‐MI exhibited an LD 50 of 5 mg/mL towards the brine shrimp ( Artemia salina ). © 1997 John Wiley & Sons, Ltd.