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Effects of ethanol extract of Annona muricata on pentylenetetrazol‐induced convulsive seizures in mice
Author(s) -
N'Gouemo P.,
Koudogbo B.,
Tchivounda H. Pambou,
AkonoNguema C.,
Etoua Minko M.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199705)11:3<243::aid-ptr66>3.0.co;2-a
Subject(s) - pentylenetetrazol , tonic (physiology) , annona muricata , medicine , epilepsy , convulsion , annonaceae , pharmacognosy , convolvulaceae , ethanol , anesthesia , pharmacology , traditional medicine , anticonvulsant , biology , biological activity , botany , psychiatry , biochemistry , in vitro
The effects of an ethanol extract of the mature leaves of Annona muricata (Annonaceae), were investigated on pentylenetetrazol (PTZ)‐induced clonic‐tonic seizures in mice. The latency of clonic PTZ seizures and the incidence of clonic and tonic episodes of PTZ seizures were analysed. The results demonstrated that the plant extract significantly reduced the incidence of tonic PTZ seizures and mortality, and lengthened the onset to clonic PTZ seizures. This study indicates that extract of the leaves of A. muricata contains active substance(s) that preferentially suppressed the tonic phase of PTZ‐induced clonic‐tonic seizures. © 1997 John Wiley & Sons, Ltd.