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Metabolic and Renal Changes Following the Ingestion of African Mistletoe Extract in Rats
Author(s) -
Obatomi D. K.,
Oye A. A. A.,
Jangber Z. N.,
Temple V. J.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199703)11:2<171::aid-ptr60>3.0.co;2-t
Subject(s) - vernonia amygdalina , ingestion , creatinine , viscum album , urine , oral administration , excretion , pharmacognosy , traditional medicine , phytotherapy , aqueous extract , medicine , cholesterol , chemistry , biology , pharmacology , biological activity , biochemistry , in vitro , alternative medicine , pathology
The effect of an aqueous extract of African mistletoe ( Loranthus begwensis ) from two host plants ( Citrus limon [Cl‐mistletoe] or Vernonia amygdalina [Va‐mistletoe]) was studied in male Wistar rats treated orally with either 1.32, 13.2 or 26.4 g/kg per day for 7 days. A significant dose‐dependent reduction ( p <0.01) in the serum glucose and cholesterol was obtained with both extracts, accompanied by a reduction of urine flow rate and serum creatinine. Increases in urinary enzymes and protein excretion were dose‐related and dependent on the source of extracts. Mistletoe extract irrespective of source appears to lower the blood sugar level offering the potential for clinical use of the ingredients of its extracts. © 1997 by John Wiley & Sons, Ltd.