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Antifertility Effects of Aqueous and Steroidal Extracts of Neem Leaf ( Azadirachta indica ) in Male Wistar Rats
Author(s) -
Parshad Omkar,
Gardner M. T.,
The T. L.,
Williams L. A. D.,
Fletcher C. K.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199703)11:2<168::aid-ptr59>3.0.co;2-#
Subject(s) - azadirachta , traditional medicine , pharmacognosy , aqueous extract , meliaceae , biology , medicine , in vitro , biological activity , biochemistry
The antifertility efficacy of both aqueous and steroidal extracts of neem ( Azadirachta indica A. Juss) leaves was studied in male Wistar rats. Intraperitoneal injections of the steroidal extract at a dose of 100 mg/kg body weight, twice a week for 10 weeks resulted in impaired spermiogenesis, increased the number of headless spermatozoa and significantly decreased ( p <0.01) motility of cauda spermatozoa, leading to a decline in the fertility index. Feeding of a 0.8% (w/v) aqueous neem leaf extract in drinking water for 7 weeks decreased serum testosterone ( p <0.01) but no effect was observed in the fertility index. © 1997 by John Wiley & Sons, Ltd.