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Investigations into the Folkloric Antimicrobial Activities of Landolphia owrrience
Author(s) -
Ebi G. C.,
Ofoefule S. I.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199703)11:2<149::aid-ptr43>3.0.co;2-n
Subject(s) - antimicrobial , candida albicans , bacillus subtilis , aspergillus niger , traditional medicine , glycoside , corpus albicans , agar , agar diffusion test , butanol , chemistry , pharmacognosy , microbiology and biotechnology , biology , antibacterial activity , food science , biological activity , bacteria , biochemistry , medicine , stereochemistry , ethanol , genetics , in vitro
The folkloric antimicrobial activities of Landolphia owrrience were investigated using ether, ethylacetate and n ‐butanol extracts of the leaves as well as six TLC components (A–F) of the n ‐butanol extract. The activities of these extracts and TLC components were investigated against Escherichia coli, Bacillus subtilis, Candida albicans and Aspergillus niger using the agar diffusion method. The n ‐butanol fraction as well as its TLC fractions showed marked antimicrobial activities against the four organisms. The n ‐butanol extract was active against all the organisms except B. subtilis . The TLC fractions A, D and E showed similar antimicrobial spectra and were active against E. coli, B. subtilis and C. albicans. Fractions B and F possessed similar antimicrobial spectra, showing activity against B. subtilis and C. albicans . Fractions B and F have the greatest fungicidal activity while fraction A has the greatest antibacterial activity based on the MIC results. These activities have been attributed to the presence of steroids, saponins, tannins and saponins probably as glycosides. © 1997 by John Wiley & Sons, Ltd.