Premium
Anti‐human immunodeficiency virus type 1 (HIV‐1) activity of Achyrocline flaccida Wein DC and Gamochaeta simplicicaulis aqueous extracts
Author(s) -
Salomón H.,
Pampuro S.,
Cavallaro L.,
García G.,
Coussio J.,
Campos R.
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199702)11:1<82::aid-ptr35>3.0.co;2-s
Subject(s) - pharmacognosy , human immunodeficiency virus (hiv) , in vitro , virus , biology , virology , biological activity , microbiology and biotechnology , traditional medicine , medicine , biochemistry
The anti‐human immunodeficiency virus type‐1 (HIV‐1) activity of two South American plant extracts was studied in vitro . The concentrations of aqueous extracts of Achyrocline flaccida Wein DC (AF) and Gamochaeta simplicicaulis (GS) that inhibit 50% of viral production were 3 and 5 μg/mL respectively. The concentrations that inhibit cellular growth were 400 and 600 μg/mL. Non‐virucidal activity was detected. The results indicate that the potent anti‐HIV‐1 activities of both AF and GS extracts might occur at an early step of viral replication on infected lymphocytes of primary origin. © 1997 John Wiley & Sons, Ltd.