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Effects of rhubarb extract in rats with diabetic nephropathy
Author(s) -
Yokozawa Takako,
He LiQun,
Muto Yasuko,
Nagasaki Rika,
Hattori Masao,
Oura Hikokichi
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199702)11:1<73::aid-ptr30>3.0.co;2-8
Subject(s) - diabetic nephropathy , creatinine , medicine , streptozotocin , diabetes mellitus , blood urea nitrogen , nephropathy , urine , urinary system , traditional medicine , excretion , endocrinology , pharmacology
Rhubarb extract was given orally to rats with diabetic nephropathy induced by subtotal nephrectomy and injection of streptozotocin. As a result, high blood and urinary glucose levels, which were conspicuous in similarly treated rats that were not given rhubarb extract, were ameliorated. Furthermore, improvement of hyperlipidaemia, and accelerated excretion of urinary urea nitrogen and creatinine were observed. These findings indicate that rhubarb extract has potential as a new therapeutic agent for inhibiting the progression of diabetic nephropathy. © 1997 John Wiley & Sons, Ltd.