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Hepatotoxic Effect of Aralia mandshurica dried root extract in pigs
Author(s) -
Burgos Rafael A.,
Hancke Juan L.,
Cáceres Dante D.,
Wilkman Georg,
Fuenzalida Hector
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199702)11:1<59::aid-ptr944>3.0.co;2-8
Subject(s) - alkaline phosphatase , traditional medicine , chemistry , subclinical infection , biology , zoology , medicine , biochemistry , enzyme
The hepatotoxic effect of a dried root extract of Aralia mandshurica over a period of 60 days (0.16 g/kg, 1.5 g/kg and 3 g/kg) was studied in Landrace pigs of both sexes. The toxic effect of Aralia mandshurica was evaluated by measuring serum alanine amino transferase (ALT), gamma glutamil transpeptidase (gGT) and serum alkaline phosphatase (SAP). Blood samples were obtained by venopuncture on days 0, 7, 30, and 60 after the administration of Aralia mandshurica and the body weight was registered weekly. At the end of the experiment the liver was examined histologically. The levels of ALT and gGT were increased significantly with all the concentrations of Aralia mandshurica at day 60. A subclinical hepatitis characterized by the presence of lymphocytes and polymorphonuclears in the portal and periportal region was observed. A hepatobiliary toxic effect of Aralia mandshurica dried root extract after chronic administration in pigs is concluded.