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An alkaloidal extract (ALKS1) from Trophis racemosa lowers intraocular pressure in dogs
Author(s) -
GossellWilliams Maxine D.,
West Manley E.,
Simon Oswald
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199702)11:1<57::aid-ptr943>3.0.co;2-h
Subject(s) - atropine , intraocular pressure , traditional medicine , medicine , muscarinic acetylcholine receptor , pharmacology , chemistry , anesthesia , ophthalmology , receptor
A 1.0% solution of ALKS1, an alkaloidal extract obtained from Trophis racemosa , produced a significant fall in intraocular pressure in the dog's eye ( p <0.001). The fall was antagonized by atropine ( p <0.0025), suggesting ALKS1 is acting through a muscarinic mode of action. Further purifcation of the extract is required to determine the actual compound producing this effect on the eye. © 1997 John Wiley & Sons, Ltd.