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HIV‐1 reverse transcriptase inhibitory principles from Chamaesyce hyssopifolia
Author(s) -
Lim Yasmina A.,
Mei Ma Chao,
Kusumoto Ines T.,
Miyashiro Hirotsugu,
Hattori Masao,
Gupta Mahabir P.,
Correa Mireye
Publication year - 1997
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199702)11:1<22::aid-ptr951>3.0.co;2-3
Subject(s) - reverse transcriptase , human immunodeficiency virus (hiv) , ic50 , virology , enzyme , inhibitory postsynaptic potential , traditional medicine , biology , pharmacology , medicine , biochemistry , in vitro , rna , endocrinology , gene
In the course of our studies on the development of anti‐acquired immunodeficiency syndrome (AIDS) agents, we isolated corilagin, quercetin 3‐ O ‐β‐ D ‐glucopyranoside and 1,3,4,6‐tetra‐ O ‐galloyl‐β‐ D ‐glucopyranose from Chamaesyce hyssopifolia , as the main inhibitory substances against human immunodeficiency virus (HIV) reverse transcriptase, an enzyme essential for the proliferation of HIV. The IC 50 of these substances were 20, 50 and 86 μ M , respectively, their modes of inhibition being non‐competitive with respect to the substrate. © 1997 John Wiley & Sons, Ltd.