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Effects of Hypericum calycinum L. Extract on the Central Nervous System in Mice
Author(s) -
Öztürk Yusuf,
Aydin Süleyman,
Beis Rana,
Can Başer K. Hüsnü,
Berberoğlu Hülya
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199612)10:8<700::aid-ptr929>3.0.co;2-x
Subject(s) - desipramine , hypericum , central nervous system , pharmacology , hypericum perforatum , fluoxetine , pharmacognosy , traditional medicine , antidepressant , biology , medicine , biological activity , neuroscience , hippocampus , serotonin , in vitro , biochemistry , receptor
Hypericum species have been used as herbal remedies for the therapy of various neurological disorders. In the present study, the effects of Hypericum calycinum on the central nervous system were investigated using various behavioural models including swimming time, locomotor activity, tail‐flick and hole‐board experiments. According to the results obtained, it was found that the extract prepared from H. calycinum is as effective as the antidepressant drugs, desipramine and trimipramine, which were used for comparison with this plant extract in animal models.