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Antimalarial Active Principles of Spathodea campanulata Stem Bark
Author(s) -
Amusan Oluwole O. G.,
Adesogan Ezekiel K.,
Makinde Janet M.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199612)10:8<692::aid-ptr928>3.0.co;2-o
Subject(s) - ursolic acid , bark (sound) , traditional medicine , chemistry , biology , medicine , chromatography , ecology
Antimalarial principles of Spathodea campanulata stem bark extract were isolated and characterized. The antimalarial principles in the stem bark were 3β‐hydroxyurs‐12‐en‐28‐oic acid (ursolic acid) and two of its derivatives; 3β‐hydroxyurs‐12,19‐dien‐28‐oic acid (tomentosolic acid) and 3β,20β‐dihydroxyurs‐12‐en‐28 oic acid. This is the first report of the isolation of ursolic acid and its derivatives as antimalarial compounds