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Extracts from Blighia sapida (Koenig) Produce Neutropenia and Thrombocytopenia in Mice
Author(s) -
Gardner Michael T.,
Williams L. A. D.,
The T. L.,
Fletcher C. K.,
Singh P. D. A.,
Wharfe G.,
Chookang E.,
Sawh R. N.,
Rickards E.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199612)10:8<689::aid-ptr927>3.0.co;2-7
Subject(s) - polycythaemia , neutropenia , platelet , medicine , aqueous extract , absolute neutrophil count , immunology , pharmacology , gastroenterology , traditional medicine , chemotherapy
Neutrophil and platelet counts were significantly lowered ( p <0.05) in mice treated with aqueous and lipid extracts of the unripe fruit of Blighia sapida. The percentage reduction in neutrophil and platelet counts relative to the controls for the aqueous and lipid (data in parentheses) extracts were 63.4% (59.3%) and 37.46% (32.44%) respectively after 6 weeks of treatment. The significant reduction in neutrophil and platelet numbers suggests that these extracts may be useful in disease conditions where these two blood parameters are elevated, for example chronic myeloid leukaemia, essential thrombocythaemia and polycythaemia.