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Biological Activity and Xanthine Oxidase Inhibitors from Scirpus californicus (C. A. Mey.) Steud.
Author(s) -
SchmedaHirschmann G.,
Gutiérrez M. I.,
Loyola J. I.,
Zúñiga J.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199612)10:8<683::aid-ptr916>3.0.co;2-t
Subject(s) - xanthine oxidase , piceatannol , biology , rhizome , bioassay , enzyme , biochemistry , biological activity , pharmacognosy , in vitro , chemistry , botany , genetics , resveratrol
The methanol extract of the rhizomes of Scirpus californicus (Cyperaceae) inhibited the enzyme xanthine oxidase (XO) in vitro . Bioassay‐guided isolation led to piceatannol, scirpusin A and scirpusin B as the main XO inhibitors of S. californicus. Piceatannol, scirpusin A and B were mixed‐type inhibitors of the XO with K i values of 1.1×10 −4 , 6×10 −4 and 5×10 −5 M , respectively. The extract and above mentioned compounds were marginally active as hypotensors when tested in normotensive rats at 2.5 mg/kg and were inactive towards the DNA binding assay in vitro .