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Hypoglycaemic Agent(s) in Leaves of Elaeophorbia drupifera
Author(s) -
Eno A. E.,
Itam E. H.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199612)10:8<680::aid-ptr881>3.0.co;2-c
Subject(s) - glibenclamide , oral administration , medicine , pharmacology , traditional medicine , endocrinology , diabetes mellitus
Male white Wistar rats (250–300 g), after an overnight fast, were treated with a crude extract (20 mg/kg oral) from the leaves of E. drupifera . The extract was administered 2 h before and 2 h after either an oral glucose load (3 g/kg) or a subcutaneous injection of adrenaline (0.01 mg/kg). The results showed that the extract reduced the blood glucose levels in rats that received the extract 2 h before glucose and adrenaline administration by about 34.3% and 35.2%, respectively. For the group that received the extract 2 h after glucose and adrenaline administration, the blood glucose levels were reduced by about 52.8% and 29.7%, respectively. Comparison was made between the action of the extract and a known hypoglycaemic drug — glibenclamide (0.29 mg/kg oral). The extract (20 mg/kg oral) was found to be faster and more effective than glibenclamide in lowering the blood glucose levels in fasting rats.