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In Vivo Hepatoprotective Effect of Baicalein, Baicalin and Wogonin from Scutellaria rivularis
Author(s) -
Lin ChunChing,
Shieh DenEn
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199612)10:8<651::aid-ptr651>3.0.co;2-l
Subject(s) - baicalein , baicalin , wogonin , scutellaria baicalensis , carbon tetrachloride , pharmacology , hepatotoxin , liver injury , in vivo , aspartate transaminase , ccl4 , medicine , chemistry , toxicity , transaminase , kampo , traditional medicine , biochemistry , alkaline phosphatase , traditional chinese medicine , biology , pathology , enzyme , high performance liquid chromatography , alternative medicine , organic chemistry , microbiology and biotechnology , chromatography
The in vivo hepatoprotective effect of baicalein, baicalin and wogonin, three major components isolated from Scutellaria rivularis Benth. were investigated in three experimental models. Liver damage was induced by acetaminophen (APAP), carbon tetrachloride (CCl 4 ) and β‐ D ‐galactosamine ( D ‐GalN) in rats. Significant protective effects were seen by comparing the serum glutamate oxaloacetate transaminase (sGOT), serum glutamate pyruvate transaminase (sGPT) and histopathologic examination. All tested drugs, especially wogonin (5 mg/kg), markedly decreased the toxicity produced by D ‐GalN ( p <0.01). Wogonin (5, 10 mg/kg) also decreased APAP‐induced hepatotoxicity. Baicalin (10 mg/kg) exhibited the best hepatoprotective effect on CCl 4 ‐induced liver injuries, but had no significant effect on APAP‐induced intoxication. In histopathologic observation, hepatic lesions caused by three hepatotoxins were markedly improved in drug‐treated groups, compared with glycyrrhizin (GLZ) as a standard reference medicine.