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Berberis aristata Inhibits PAF Induced Aggregation of Rabbit Platelets
Author(s) -
Tripathi Yamini B.,
Shukla Shivendra D.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199611)10:7<628::aid-ptr913>3.0.co;2-x
Subject(s) - platelet , berberidaceae , platelet activating factor , pharmacology , berberis , chemistry , platelet aggregation , lagomorpha , pharmacognosy , traditional medicine , biochemistry , biological activity , medicine , in vitro , immunology
Berberis aristata (Berberidaceae) is in use in the Ayurvedic system of medicine for the management of various allergic disorders. For the first time the anti‐PAF (platelet activating factor) activity of the alcohol extract of the root of B. aristata has been studied on rabbit platelets. It inhibits the PAF induced aggregation of platelets in a dose dependent manner in the microgram range. It also inhibits the 3 H‐PAF binding to rabbit platelets in a competitive manner.