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Additional Antibacterial Diterpenes from the Bark of Juniperus procera
Author(s) -
Muhammad Ilias,
Mossa Jaber S.,
ElFeraly Farouk S.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199611)10:7<604::aid-ptr922>3.0.co;2-c
Subject(s) - diterpene , bark (sound) , procera , antibacterial activity , stereochemistry , chemistry , botany , traditional medicine , biology , bacteria , medicine , ecology , genetics
The bark of Juniperus procera yielded the diterpene 7β‐hydroxyabieta‐8,13‐dien‐11,12‐dione (1) with strong activity against Mycobacterium species, and the hitherto unreported bisnorlabdane derivative 14,15‐bisnor‐13‐oxolabd‐8(17),11( E )‐dien‐19‐oic acid (4). In addition, the bark yielded the known compounds crypotrienolic acid, isocupressic acid and sugiol. Structural assignments were largely based on the spectral data, including those derived from 2D NMR COSY and HETCOR experiments.