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Effect of Extract of Leaf and Seed of Piper guineense on Some Smooth Muscle Activity in Rat, Guinea‐pig and Rabbit
Author(s) -
Udoh Francis V.,
Akpan Jones O.,
Ufaruthaniel
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199611)10:7<596::aid-ptr915>3.0.co;2-t
Subject(s) - jejunum , guinea pig , ileum , atropine , piper , biology , uterus , contraction (grammar) , smooth muscle , rabbit (cipher) , muscle contraction , traditional medicine , pharmacology , endocrinology , botany , medicine , statistics , mathematics
Extracts of the leaf and seed of Piper guineense were separately prepared and their pharmacological effects screened using smooth muscle of the gastrointestinal tract and uterus. The leaf extract enhanced both the frequency and tone of spontaneous contractions of rabbit jejunum and induced contraction of guinea‐pig ileum, which were blocked by atropine. The seed extract had the opposite effect on rabbit jejunum, an inhibition which was antagonized by prazocin, and little or no effect on guinea‐pig ileum. Both extracts had a stimulant effect on rat uterine muscle, the seed extract to a lesser extent.