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Topical Antiinflammatory Activity of Two Pimarane Diterpenes from Kaempferia pulchra
Author(s) -
Sematong Tuanta,
Reutrakul Vichai,
Tuchinda Patoomratana,
Claeson Per,
Pongprayoon Ubonwan,
Nahar Nilufar
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199609)10:6<534::aid-ptr890>3.0.co;2-c
Subject(s) - zingiberaceae , traditional medicine , pharmacognosy , terpenoid , biology , medicine , pharmacology , botany , rhizome , biological activity , in vitro , biochemistry
Two diterpenes, 2α‐acetoxysandraracopimaradien‐1α‐ol (1) and sandaracopimaradien‐1α,2α‐diol (2) isolated from Kaempferia pulchra Ridl. (Zingiberaceae), have been assayed for topical antiinflammatory activity in the model of 12‐O‐tetradecanoylphorbol‐13‐acetate‐induced ear oedema in rats. Both substances were found active and the ID 50 ‐values were estimated to 330 and 50 μg/ear, respectively. The ID 50 ‐value of the reference drug diclofenac was calculated to 90 μg/ear