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Pharmacological Actions of Naringin on Alpha, Beta‐adrenoceptors and Uptake of Noradrenaline in Rat Isolated Vas Deferens
Author(s) -
Herrera M. D.,
Marhuenda E.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199609)10:6<523::aid-ptr885>3.0.co;2-2
Subject(s) - vas deferens , naringin , yohimbine , prazosin , propranolol , pharmacology , chemistry , alpha (finance) , endocrinology , medicine , receptor , chromatography , antagonist , surgery , construct validity , patient satisfaction
In normal Krebs solution, naringin (1×10 −7 M sc–2×10 −6 M ) enhanced noradrenaline‐induced contractions in rat isolated vas deferens increasing this potentiation in a concentration dependent manner. This enhancing effect continued in the presence of yohimbine (10 −6 M ) or propranolol (10 −6 M ). Naringin did not modify significantly the dopamine dose‐response curves. In a medium containing 10 −8 M prazosin, naringin decreased noradrenaline dose‐response curves underneath the control curve at all the doses tested. Naringin did not modify significantly the NA dose‐response curve in a medium containing cocaine (10 −5 M ) or oestradiol (10 −5 M ). The potentiation produced by naringin on the NA‐induced contractions in rat vas deferens may be due to alpha‐1 receptor activation, together with an interference of naringin in catecholamine uptake process.