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Toxicological Evaluation of Fenugreek Seeds: a Long Term Feeding Experiment in Diabetic Patients
Author(s) -
Sharma R. D.,
Sarkar A.,
Hazra D. K.,
Misra B.,
Singh J. B.,
Maheshwari B. B.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199609)10:6<519::aid-ptr873>3.0.co;2-t
Subject(s) - creatinine , bilirubin , alkaline phosphatase , ingestion , urea , medicine , toxicity , diabetes mellitus , traditional medicine , pharmacognosy , body weight , endocrinology , chemistry , biochemistry , biological activity , enzyme , in vitro
Toxicological evaluation of fenugreek seeds was made in 60 NIDDM subjects in a 24 week study in which changes in body weight, clinical signs and symptoms and serum parameters such as SGOT, SGPT, alkaline phosphatase, bilirubin, creatinine and blood urea, together with haematological parameters, was studied. Ingestion of an experimental diet containing 25 g fenugreek seed powder resulted in no renal or hepatic toxicity, but interestingly blood urea levels were seen to decrease after week 12.