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Lipid Lowering Activity of Guggulsterone from Commiphora mukul in Hyperlipaemic Rats
Author(s) -
Chander Ramesh,
Khanna A. K.,
Kapoor N. K.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199609)10:6<508::aid-ptr895>3.0.co;2-p
Subject(s) - cholesterol , chemistry , endocrinology , sterol o acyltransferase , medicine , pharmacology , high density lipoprotein , lecithin , catabolism , blood lipids , enzyme , lipoprotein , biochemistry , biology
The lipid lowering action of guggulsterone, the active constituent of guggulipid, has been studied in triton and cholesterol fed hyperlipaemic rats. Serum lipids were found to be lowered by guggulsterone (50 mg/kg, b.w.) in triton WR‐1339 induced hyperlipaemia. Chronic feeding of this drug (5 mg/kg, b.w.) in animals simultaneously fed with cholesterol (25 mg/kg, b.w.) for 30 days, caused lowering in the lipid and apoprotein levels of very low density and low density lipoproteins in experimental animals. Guggulsterone activates lipolytic enzymes in plasma and liver as well as stimulated receptor mediated catabolism of low density lipoprotein. The hypolipidaemic activity of this drug is mediated through inhibition of hepatic cholesterol biosynthesis, increased faecal bile acid excretion and enhanced plasma lecithin:cholesterol acyltransferase activity.