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Suppression of Hepatitis B Virus Surface Antigen Secretion by Traditional Plant Medicines
Author(s) -
Goto Wakana,
Kusumoto Ines Tomoco,
Kadota Shigetoshi,
Namba Tsuneo,
Kurokawa Mashahiko,
Shiraki Kimiyasu
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199609)10:6<504::aid-ptr894>3.0.co;2-3
Subject(s) - hbsag , traditional medicine , secretion , bark (sound) , hepatitis b virus , rhizome , antigen , cassia , pharmacology , biology , virology , virus , medicine , chemistry , immunology , biochemistry , traditional chinese medicine , ecology , alternative medicine , pathology
Forty‐three extracts of herbal medicines were tested for suppressing the secretion of hepatitis B virus (HBV) surface antigen (HBsAg) in vitro . Fourteen extracts were found to have appreciable effects in the experimental system using the PLC/PRF/5 cell line. Of them, the extracts of Rheum palmatum (rhizome), Poligonum cuspidatum (root), Panax japonicum (root) and Terminalia arjuna (bark) strongly suppressed the secretion of HBsAg. The active constituents of these extracts absorbed through the gastrointestinal tract of guinea‐pigs suppressed the secretion of HBsAg in the PLC/PRF/5 cell culture.