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In vitro Activity of Extracts from Polyporaceae against Human Immunodeficiency Virus Type 1
Author(s) -
Walder R.,
Kalvatchev Z.,
Garzaro D.,
Barrios M.
Publication year - 1996
Publication title -
phytotherapy research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.019
H-Index - 129
eISSN - 1099-1573
pISSN - 0951-418X
DOI - 10.1002/(sici)1099-1573(199609)10:6<497::aid-ptr892>3.0.co;2-v
Subject(s) - vesicular stomatitis virus , biology , virology , cytopathic effect , virus , interferon , in vitro , cell culture , cytotoxicity , viral replication , vesicular stomatitis , microbiology and biotechnology , biochemistry , genetics
Aqueous extracts of Fomitella supina, Phellinus rhabarbarinus, Trichaptum perrottettii, and Trametes cubensis (Polyporaceae) from the Amazonian rain forest of Venezuela exhibited differential cytotoxicity and inhibitory activity against the human immunodeficiency virus type 1 (HIV‐1). These extracts inactivated extracellular virions and suppressed HIV‐1 replication by blocking HIV‐1‐induced cell–cell fusion in an in vitro culture system. They also stimulated interferon (IFN) production, active against HIV‐1 and vesicular stomatitis virus (VSV) cytopathic effects. The results suggest that these extracts contain novel anti‐HIV active compounds which, individually or in combination, can exert several distinct suppressive effects. The test extracts appear to act specifically at the level of CD4‐gp120 binding.